Philosophy professor Walter Zarrow is wounded during a mugging. In an effort to escape he rings buzzers indiscriminately, waking Sam, a middle aged father of two having an affair in the city. Sam reluctantly answers Zarrow's pleas, and Zarrow loses consciousness in his arms. Through an exploration of why these men, along with the mugger, and an addict named Joe, come together, we explore New York City. The experience of Zarrow, Sam, Joe and Zarrow's assailant ripple quickly out to include the connected lives of a housewife struggling with alcoholism, a stoner teen desperate to lose his virginity, a brilliant but failed writer fighting addiction, two parents confronting the prospect of terminal illness, and a brilliant grad student who wounds herself to feel alive.

The true story of Dr. Miklos Nyiszli, a Hungarian Jew chosen by Josef Mengele to be the head pathologist at Auschwitz. Nyiszli was one of Auschwitz's Sonderkommandos - Special Squads of Jewish prisoners placed by the Nazis in the excruciating moral dilemma of helping to exterminate fellow Jews in exchange for a few more months of life. Together, the Sonderkommandos struggled to organize the only armed revolt that would ever take place at Auschwitz. As the rebellion is about to commence, a group from the unit discovers a 14-year-old girl who has miraculously survived a gassing. A catalyst for their desperate attempt at personal redemption, the men become obsessed with saving this one child, even if doing so endangers the uprising which could save thousands. To what terrible lengths are we willing to go to save our own lives, and what in turn would we sacrifice to save the lives of others?